m-PEG7-4-nitrophenyl carbonate
CAS No.: 678150-56-6
Cat No.: BP-501525
4.5 
m-PEG7-4-nitrophenyl carbonate is a monofunctional PEG-based linker featuring a methoxy-terminated polyethylene glycol chain of intermediate length and a 4-nitrophenyl carbonate group at the opposite end. Structurally, the carbonate provides a stable handle for conjugation while the 4-nitrophenyl group serves as an activated phenyl carbonate moiety that can undergo nucleophilic substitution under appropriate conditions, enabling attachment to primary amines, hydrazines, or other nucleophiles commonly used to install functional groups on PROTAC warheads or ligands. In PROTAC design, this linker is valuable for modular assembly because it preserves PEG-mediated solubility and conformational flexibility, while the carbonate chemistry allows efficient coupling to generate defined conjugates for subsequent ternary complex formation. Researchers use PEGylated carbonate linkers to tune steric and hydrophilic properties, improve handling of conjugates, and facilitate systematic structure–activity studies in targeted protein degradation workflows.
Structure of 678150-56-6
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m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker reagent designed to enable efficient installation of carbonate-linked handles for assembling targeted protein degradation constructs. Its PEG segment provides aqueous compatibility and tunable spacing, while the activated 4-nitrophenyl carbonate leaving group supports robust nucleophilic substitution. These features make it useful for modular PROTAC synthesis, where linker length and chemoselective coupling strongly influence conjugate properties; the following sections describe the structure and reactivity in detail below.
Structure: The molecule contains a polyethylene glycol chain connected to a carbonate functional group, with an aryl 4-nitrophenyl moiety attached to the carbonate oxygen. It features ether linkages within the PEG domain and a carbonate linkage, providing flexibility, polarity, and improved solubility in aqueous media.
Reactivity: As an activated aryl carbonate, it undergoes nucleophilic acyl substitution with appropriate nucleophiles commonly used in PROTAC assembly, such as amines or alcohols, to form new carbonate or carbamate linkages. Reaction conditions are typically mild and conducted in polar organic solvents or mixed solvent systems to maintain solubility and reactivity, often using base to promote nucleophile formation. The 4-nitrophenyl group acts as the leaving group, enabling clean coupling under standard synthetic protocols.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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