DNP-PEG12-acid
Cat No.: BP-501919
4.5 
DNP-PEG12-acid is a heterobifunctional polyethylene glycol (PEG) linker bearing a DNP (dinitrophenyl) functional group and a terminal carboxylic acid, providing a flexible, hydrophilic spacer of approximately twelve ethylene glycol units. Structurally, the PEG chain confers conformational mobility and aqueous solubility, while the carboxylate enables straightforward conjugation to amine- or hydrazide-bearing targeting ligands and other PROTAC components through standard coupling chemistries. In targeted degradation workflows, the DNP moiety can serve as a recognition handle for DNP-binding systems, allowing the linker to position two molecular partners in proximity to promote ternary complex formation. This makes DNP-PEG12-acid useful for constructing PROTAC-like degraders and related conjugates where controlled spacing and reliable linkage chemistry are critical for efficient recruitment and subsequent ubiquitin-dependent processing.
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* For research and manufacturing use only. Not for human or clinical use.
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DNP-PEG12-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to connect a DNP-derived targeting handle to a protein-binding moiety while providing conformational flexibility and improved solubility in typical organic and mixed aqueous systems. Its PEG spacer architecture can help tune effective reach and reduce steric constraints at the ternary complex interface. The details below describe its structural features and the practical considerations for assembling PROTAC conjugates using this linker.
Structure: This linker contains a PEG chain terminated with a carboxylic acid functionality, enabling stable amide or ester-forming coupling chemistry. The structure is dominated by ether linkages along the PEG backbone, with a terminal acid group that supports controlled derivatization and predictable polarity.
Reactivity: The terminal carboxylic acid is suitable for activation toward PROTAC bond formation, commonly via carbodiimide-mediated coupling or acid-derivatization strategies that generate reactive intermediates. Typical workflows employ polar aprotic solvents and controlled pH to promote amide bond formation with compatible amine-bearing partners. Reaction conditions are selected to preserve sensitive targeting ligands and maintain linker integrity during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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